Fish as bio indicators have a very important role in monitoring the pollution of aquatic biotopes, as they are much sensitive to the presence of ksenobionts in the aquatic environments. Water pollution with ksenobionts (industrial pollutants, agricultural pollutants, etc.), affects in the metabolic processes of the aquatic organisms. After the penetration and absorption of ksenobit from the body, they reach biotransformation, or get conjugated with the specific structures of the cell such as specific receptors located in the peripheral part of the cell, the cell membrane and inside its cytoplasm and also in the cell organelles. ksenobiont’s connection with membrane receptors can initiate cellular processes that have toxic effects or other adverse effects on the cell itself. Such processes have negative effects in the organism which afterwards these are affected with the body organs or the whole population. As meaningful indicators that can determine the detection of ksenobionts in the aquatic environment of fish are biological markers. As a safe and adequate biomarker to determine the pollution of aquatic biotopes is cytochrome P4501A (Anzenbacherova and Anzenbacher 1999).

The massif mountain of Sharr is considered as the greatest asset of the country and region, both in terms of natural abundance, recreation, tourism and in terms of the cultivation of goods. Special attention should be paid to the protection and preservation of the natural biodiversity as a natural asset that requires a serious approach to the preservation and protection of the environment of this massif from the population that lives in these areas, country and the region in general. In terms of recreation and tourism the massif mountain of Sharr was earlier known for the winter recreational sports, tourism and summer recreation. Special attention should be given to the alpine places which are more attractive for hunting, grazing, water resources and in particular it is the most attractive for its flora and fauna. Special attention should be given to the endemic highlights of the flora and fauna and to the conservation aspect of this biotope. One must have an interest and passion to further invest in capital projects for this massif mountain with the only aim to further increase the spotted recreational picturesque places of the Sharr Mountain.